…lar concentrations of the lead compounds depletes predominantly the HIV-infected cells and in doing so markedly enriches the pool of the uninfected cells. Affinity of the lead compounds to the viral protease is validated computationally and experimentally but despite expectations, the mechanism of action of the synthesized toxins is shown to be independent from the enzymatic activity of the HIV protease….
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“Chemical zymogens for the protein cysteinome“ https://doi.org/10.1038/s41467-022-32609-1 We present three classes of chemical zymogens established around the protein cysteinome. In each case, the cysteine thiol group was converted into a mixed disulfide: with a small molecule, a non-degradable polymer, or with a fast depolymerizing fuse polymer (ZLA). The latter was a polydisulfide based on naturally occurring molecule, lipoic acid. Zymogen desi…
…4, an endogenous peptide antagonist of CXCR4. We synthesized macromolecular peptide conjugates and performed side-by-side comparison with their albumin-binding counterparts and considered monovalent conjugates, divalent telechelic conjugates, and Y-shaped peptide dimers. All constructs were tested for competition with the CXCR4 antibody–receptor engagement, inhibition of receptor activation, and inhibition of the CXCR4-tropic human immunodeficienc…
…An Invited Feature Article is published in Advanced Functional Materials : together with Dr. Brigitte Stadler (iNano, Aarhus University) and Dr. Andrew Price (Sandia National Laboratories) we provide “A Critical Look at Multilayered Polymer Capsules in Biomedicine: Drug Carriers; Artificial Organelles, Cell Mimics“….
…Our lab sincerely welcomes Mille Bergkvist Lauridsen Kryger, Medicinal Polymer Chemistry newest PhD student ! Mille did her BSc project at the cDNA Center with Prof. Kurt V. Gothelf followed by a Chemistry project and joins the group after receiving her master degree in Marts 2011….
…Medicinal Polymer Chemistry lab contributed to a publication in Journal of Physical Chemistry, B entitled “Exploiting Fluorescent Polymers to Probe the Self-Assembly of Virus-like Particles”….
…The Medicinal Polymer Chemistry lab has published a concept article in cooperation with Dr. Andrew Price (Sandria National Laboratories) and Dr. Brigitte Stadler (iNano, Aarhus University). The paper discusses “Poly(methacrylic acid) polymer hydrogel capsules: Drug carriers, sub-compartmentalized microreactors, artifical organelles” and has been published in Small 2010, 6, 2201-2207 ….
…le: Construction of Polyelectrolyte multilayers. Overview and one specific example. SELECTED CONFERENCE PRESENTATIONS Materials Research Society meeting (Boston MA, USA, 12 / 2008) Title: Single component polymer capsules for biomedical applications International Conference on Nanoscience and Nanotechnology, (Melbourne, Australia, 02/2008) Title: Biomolecule encapsulation within degradable polymeric microcapsules 7th International Symposiumon Pol…
…Monday 9th of Januar 2023 Alex lectured in the Build-a-cell seminar series. The talk was recorded and is available on Youtube. Watch it here: https://www.youtube.com/watch?v=ukUaSp2bdDo…
…http://www.zelikin-lab.com/the-group/group-members/…