Our work “Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrug” has been published in Organic and Biomolecular Chemistry
We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chemical reactions.
