Our work “Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs” has been published in Chemical Communications. The work has been featured in the cover of the January 14th issue.
Iron-containing metallic implants are shown herein to mediate hydrolysis of glycosidic linkages. Using glucuronide prodrugs for broad-spectrum fluoroquinolone antibacterial agents, we capitalize on this behaviour and perform localized synthesis of antimicrobials which affords a significant zone of inhibition of bacterial growth around the metallic material
