“Chemical zymogens for the protein cysteinome“ https://doi.org/10.1038/s41467-022-32609-1 We present three classes of chemical zymogens established around the protein cysteinome. In each case, the cysteine thiol…
“Dimerization of the Peptide CXCR4-Antagonist on Macromolecular and Supramolecular Protraction Arms Affords Increased Potency and Enhanced Plasma Stability“ https://doi.org/10.1021/acs.bioconjchem.2c00034 Peptides are prime drug candidates due…
Our work on “Molecular, Macromolecular, and Supramolecular Glucuronide Prodrugs: Lead Identified for Anticancer Prodrug Monotherapy” has been recently published in Angewande Chemie. In this work,…
Our work “Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs” has been published in the Journal of Controlled Release. Albumin…
Our work “Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs” has been published in Chemical Communications. The work has been featured…
Our work “Identification and directed development of non‐organic catalysts with apparent pan‐enzymatic mimicry into nanozymes for efficient prodrug conversion” has just been published in Angewandte…
Our work “Combatting implant-associated biofilms through localized drug synthesis” has been recently published in the Journal of Controlled Release. Bacterial contamination of implantable biomaterials is…
Our work “Bi‐Enzymatic Embolization Beads for Two‐Armed Enzyme‐Prodrug Therapy” has been recently published in Advanced Therapeutics. Embolic beads, a successful tool for localized, site‐specific drug…
Our work “Long-Acting, Potent Delivery of Combination Antiretroviral Therapy” has been published in ACS Macro Letters. Antiretroviral therapy (ART) has revolutionized HIV treatment, yet grand…
Our recent publication “Enzyme Prodrug Therapy Achieves Site-Specific, Personalized Physiological Responses to the Locally Produced Nitric Oxide” has been published in ACS Advance Materials and…