Artificial Internalizing Receptors: Intracellular Delivery of Cargo Through Bio-Orthogonal Recognition. Søgaard, A. B., Hansson, R. F., Tvilum, A. S., Zelikin, A. N., Artificial Internalizing Receptors:…
Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis Søgaard, A. B., Løvschall, K. B., Montasell, M. C., Cramer C. B., Marcet, P. M., Pedersen, A. B., Jakobsen, J. H.,…
Artificial Internalizing Receptor Affords Fast, Potent, Specific Drug Delivery to the Chemically Engineered Cells Søgaard, A. B., Skovbo, F., Tvilum, A., Hansson, R. F., Zelikin, A. N., Artificial Internalizing Receptor…
Zymogens and Transmembrane Activation of Transcription in Synthetic Cells Andersen, D. G., Pedersen, A. B., Jørgensen, M. H., Montasell, M. C., Søgaard, A. B., Chen, G., Schroeder, A., Andersen, G. R., Zelikin, A.…
Mechanisms of Degradation for Polydisulfides: Main Chain Scission, Self-Immolation, Or Chain Transfer Depolymerization Kristensen, M. M.; Løvschall, K. B.; Zelikin, A. N., Mechanisms of Degradation…
“Antibody-Drug Conjugates to Treat Bacterial Biofilms viaTargeting and Extracellular Drug Release” https://doi.org/10.1002/advs.202301340 Abstract The treatment of implant-associated bacterial infections and biofilms is an urgent medical…
“Chemical zymogens: specificity and steroidal control ofreactivation” https://doi.org/10.1002/cbic.202300304 Abstract: Activation and masking of enzymatic activity on demand is of the highest importance in nature. It…
Signal transduction across biological membranes is among the most important evolutionary achievements. Herein, for the design of artificial cells, weengineer fully synthetic receptors with the…
“Potentiation of Drug Toxicity through Virus Latency Reversal Promotes Preferential Elimination of HIV Infected Cells” https://doi.org/10.1002/adtp.202200113 Eliminating latently infected cells is a highly challenging, indispensable…
“Chemical zymogens for the protein cysteinome“ https://doi.org/10.1038/s41467-022-32609-1 We present three classes of chemical zymogens established around the protein cysteinome. In each case, the cysteine thiol…